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  • Mjakes-Munni posted an update 1 month, 1 week ago

    Who thinks that smokers are drug addicts?

    • I suppose they are
      • Off course smokers re drug addicts!!!! More people understand now the harmful effects that smoking has on the body as well as the addictive effects of nicotine. The pervasiveness of tobacco use in our society and the frequency of altered disposition of many common therapeutic and recreational drugs in smokers makes it apparent that the smoking habit should be considered as one of the primary sources of drug interactions in man. Each scientific report dealing with drug disposition should list the smoking status of the subjects studied as smoking should be included as a basic characteristic of each subject along with age, race, body weight, and presence and type of disease. Most of the experimental work in human and animal systems indicates that the dominant effect of smoking is enhanced disposition caused by induction of hepatic microsomal enzymes. The primary causal agents are probably the polynuclear aromatic hydrocarbons which are potent and persistent in tissues. There are numerous examples of both an increased metabolism rate and absence of an effect of smoking on drug disposition in man. This selectivity is consistent with the known inductive effects of P-448 stimulators in animal systems. Studies with theophylline have demonstrated that both tobacco and marijuana markedly alter its clearance in man. However, smoking is only one of numerous factors which can perturb hepatic biotransformation as patient surveillance studies show that age and cardiac and liver disease may be of greater importance in actual patients undergoing therapy. Nicotine may “prime” the brain to enhance cocaine’s effects, making it a very dangerous “gateway drug.” That means it could open the door to other drug use. So before lighting up ; keep in mind that cigarettes re addictive and it is a drug. Live healthier and happier, while saving money…